Incidence of focal white matter lesions in a population of hemophiliac children and their normal siblings

Autor: M. A. Maeder, C. T. Kisker, H. S. Lynn, D. A. Wilson, Marvin D. Nelson, Bruce L. Evatt, S. M. Donfield, M. J. Fenstermacher
Rok vydání: 2000
Předmět:
Zdroj: Pediatric Radiology. 30:705-709
ISSN: 1432-1998
0301-0449
DOI: 10.1007/s002470000290
Popis: Objective. This analysis was undertaken to evaluate the etiology and sequelae of 2- to 5-mm focal white matter hyperintensities on T2-weighted MR images of some participants enrolled in the Hemophilia Growth and Development Study (HGDS).¶Materials and methods. The HGDS is a multicenter study of the growth and development, neurological, neuropsychological, and immune functioning of a cohort of children and adolescents, 62 % of whom were infected with HIV through the use of clotting factor concentrates, and their non-hemophiliac, non-HIV infected male siblings. The current investigation was conducted with all three groups of HGDS participants: HIV-positive hemophiliacs (n = 207), HIV-negative hemophiliacs (n = 126), and their siblings (n = 47). Magnetic resonance imaging was performed at each center, with a variety of 0.3 to 1.5 T instruments. Standard examinations included 5-mm-thick T1-weighted sagittal and axial images, intermediate, and T2-weighted axial images. A study of abnormalities of the coagulation system known to be associated with thrombotic events was conducted among a subgroup of participants (n = 51) from eight centers.¶Results. Lesions were not associated with hemophilia-related factors, immune function, hematologic, or neurologic factors. There were no associations between the presence of white matter lesions and defects of coagulation in any of the assays completed.¶Conclusion. The 2- to 5-mm focal white matter hyperintensities on T2-weighted MR images of the brain were incidental findings in our study population.
Databáze: OpenAIRE
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