Autor:	Julie K. Furne, Michael D. Levitt, Fabrizis L. Suarez, Stephen L. Ewing, John Springfield
Rok vydání:	2000
Předmět:	Physiology Gastroenterology Biological activity Pharmacology equipment and supplies medicine.disease Ulcerative colitis Bismuth subsalicylate Carrageenan chemistry.chemical_compound Metronidazole Dextran chemistry Biochemistry medicine Colitis Sulfate medicine.drug
Zdroj:	Digestive Diseases and Sciences. 45:1439-1443
ISSN:	0163-2116
DOI:	10.1023/a:1005580709390
Popis:	Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H2S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazole blocks the development of this colitis suggested that the injurious agent could be a sulfur-containing compound (such as H2S) that is released during the bacterial metabolism of the nonabsorbed sulfate. We tested this possibility by feeding rats dextran sulfate, with or without bismuth subsalicylate, a compound that avidly binds H2S. Bismuth subsalicylate reduced the fecal release of H2S in dextran sulfate-treated rats to values well below that of controls. Nevertheless, all the animals developed colitis. We conclude that excessive H2S production does not play a role in the dextran sulfate model of colitis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::df8a5533f2d443d4a35e8db639678307 https://doi.org/10.1023/a:1005580709390 Zobrazit plný text záznamu Full text from SpringerLink