A PROSPECTIVE STUDY OF THE NATURAL COURSE OF CYTOMEGALOVIRUS INFECTION AND DISEASE IN RENAL ALLOGRAFT RECIPIENTS1
| Autor: | Ellen Holter, Anders Hartmann, Solbjørg Sagedal, Torbjørn Leivestad, Aksel Foss, Kåre Osnes, Knut P. Nordal, Miklos Degré, Halvor Rollag, P. Fauchald |
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| Rok vydání: | 2000 |
| Předmět: |
Hepatitis
Human cytomegalovirus Ganciclovir Transplantation medicine.medical_specialty biology business.industry Congenital cytomegalovirus infection virus diseases biology.organism_classification medicine.disease Gastroenterology Betaherpesvirinae Internal medicine Immunology medicine Viral disease Risk factor business medicine.drug |
| Zdroj: | Transplantation. 70:1166-1174 |
| ISSN: | 0041-1337 |
| Popis: | BACKGROUND Cytomegalovirus (CMV) infection is the single most frequent infectious complication in renal transplant recipients. Because no CMV-prophylaxis is given and ganciclovir is used only as deferred therapy for CMV disease at our center, we have been able to study the natural course of CMV infections. The aim was to assess risk factors for CMV infection and disease and thus identify subgroups of patients likely to benefit from CMV prophylaxis or preemptive therapy. METHODS Between October 1994 and July 1997, 477 consecutive renal transplant recipients (397 first transplants and 80 retransplants) were included in the study. The patients were followed prospectively for 3 months with serial measurements of CMV pp65 antigen for monitoring activity of CMV infections. RESULTS The incidence of CMV infections in first transplants was 68% in D+R- and D+/-R+ serostatus groups, whereas the incidence of CMV disease was higher in D+R- (56%) than in D+/-R+ (20%, P |
| Databáze: | OpenAIRE |
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