Polyhydroxy Sterols Isolated from the Red Sea Soft Coral Lobophytum crassum and their Cytotoxic Activity

Autor:	Shadia M Azzam, Nabil M Selim, Camilia G. Michel, Abdel-Hamid A. M. Ali, Mohamed F. Hegazy, Ahmed Hussein, Elsayed A Aboutabl
Rok vydání:	2017
Předmět:	Pharmacology 010405 organic chemistry Coral Lobophytum crassum Plant Science General Medicine Sesquiterpene 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Biochemistry Drug Discovery
Zdroj:	Natural Product Communications. 12:1934578X1701200
ISSN:	1555-9475 1934-578X
DOI:	10.1177/1934578x1701200223
Popis:	One new (1) together with four known sterols (2 - 5) and a sesquiterpene (6) were isolated from a polar extract of the Red Sea soft coral Lobophytum crassum. The compounds were identified as 24-methylenecholest-5-ene-1α,3 1α,11α-triol 1-acetate (1), 24-methylenecholest-5-ene-1α,3β,11α-triol (2), 24-methylenecholest-5-ene-3β-ol (3), 24-methylenecholestane-1α,3β,5a,6P,1-pentol (4), 24-methylenecholestane-3β,5α,6β-triol (5) and alismoxide (6) based on extensive NMR analysis. The cytotoxicity of compounds 1 - 6 was evaluated in vitro using three human cancer cell lines viz., HepG2, Hep-2 and HCT-116. Compound 1 showed selective cytotoxic activity against HepG2, while 3 exhibited cytotoxicity against all tested cell lines.
Databáze:	OpenAIRE
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