Commercial Synthesis of Azilsartan Kamedoxomil: An Angiotensin II Receptor Blocker

Autor:	Nimesh C. Misra, Korupolu Raghu Babu, Ambati V. Raghava Reddy, Chandiran Takshinamoorthy, Paul Douglas Sanasi, Srinivas Garaga, Koilpillai Joseph Prabahar
Rok vydání:	2015
Předmět:	Angiotensin receptor Chromatography Chemistry Organic Chemistry AZILSARTAN KAMEDOXOMIL Azilsartan Medoxomil Physical and Theoretical Chemistry Pharmacology
Zdroj:	Organic Process Research & Development. 19:514-519
ISSN:	1520-586X 1083-6160
Popis:	A commercially viable process for the preparation of azilsartan kamedoxomil, an angiotensin II receptor blocker, has been developed. The present work describes the novel synthesis of azilsartan medoxomil from amidoxime methyl ester. The present work also describes the improved synthesis of amidoxime methyl ester and azilsartan kamedoxomil. This process features a high overall yield (36%) with 99.52% HPLC purity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::df7ba74023082e88c5d67c23867735a1 https://doi.org/10.1021/op500357r Zobrazit plný text záznamu