Pyridostigmine Bromide Alters Locomotion and Thigmotaxis of Rats
| Autor: | Bethany A. Cody, Ian R. Tebbett, Charles J. Schmidt, Donna Wielbo, S Toffollo, F. van Haaren, J B Hoy, Janet L. Karlix |
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| Rok vydání: | 1999 |
| Předmět: |
Pharmacology
Estrous cycle medicine.medical_specialty Thigmotaxis biology business.industry Clinical Biochemistry Toxicology Biochemistry Open field Behavioral Neuroscience Endocrinology Oral administration Internal medicine Blood plasma medicine biology.protein Pyridostigmine Bromide Habituation business Biological Psychiatry Cholinesterase |
| Zdroj: | Pharmacology Biochemistry and Behavior. 63:401-406 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/s0091-3057(99)00014-3 |
| Popis: | Male rats and female rats in the proestrous and metestrous stages of estrus were tested to determine the effects of pyridostigmine bromide on locomotion rate and thigmotactic response using doses of 3.0, 10.0, and 30.0 mg/kg. Thirty minutes after administration of the pyridostigmine bromide the rats were videorecorded for 2 h in a 1 m2 open-field arena. The rats' activities were analyzed for the drug's effect on speed throughout the 2 h and during six 20-min segments. Also, the times that the rats were observed moving through the central 50% of the arena were determined. Locomotion rates decreased significantly, and thigmotaxses increased significantly in all groups of rats as a dose response to pyridostigmine bromide. Habituation occurred over 2 h for both responses, primarily during the first 40 min. Female rats were more affected than males, but metestrous and proestrous females did not differ significantly in their responses. At the 30 mg/kg the effect was persistent throughout the test period. Proestrous females dosed at 30 mg/kg had much higher pyridostigmine bromide serum levels than metestrous females and males. |
| Databáze: | OpenAIRE |
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