Hypotensive and diuretic effect ofEquisetum bogotense andFuchsia magellanica and micropropagation ofE. bogotense

Autor: J. I. Loyola, Iván Razmilic, Guillermo Schmeda-Hirschmann, Jaime A. Rodríguez, P. Pacheco, Cristina Theoduloz
Rok vydání: 1994
Předmět:
Zdroj: Phytotherapy Research. 8:157-160
ISSN: 1099-1573
0951-418X
DOI: 10.1002/ptr.2650080308
Popis: Equisetum bogotense (Equisetaceae) and Fuchsia magellanica (Onagraceae) were used by the Mapuche Amerindians as diuretics. Intravenous administration of hydroalcoholic extracts to rats elicited a hypotensive response of −29.0% ±4.5% and −24.2% ±0.5% respectively in the mean blood pressure of normotensive animals at a dose of 5 mg crude extract/kg body weight. The activity was found to be related with polar compounds. For Fuchsia, the active principles are related to tannins. A single oral dose of 500 mg/kg body weight Equisetum extract produced a significant increase (p < 0.05) in the urine output in rats, while in Fuchsia a reduction in diuresis was observed. The diuretic effect of the Equisetum extract was weak compared with hydrochlorothiazide at 25 mg/kg body weight. The data presented support the use of E. bogotense in Chilean traditional medicine. A micropropagation method for E. bogotense was established by culturing shoot tips in Murashige-Skoog medium with macro and micronutrients diluted 4-fold and containing 0.1 mg/L thiamine, 100 mg/L myoinositol, 1.0 mg/L NAA and 0.1 mg/L BAP.
Databáze: OpenAIRE
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