Attenuation of Hippocampal llp-Hydroxysteroid Dehydrogenase Type 1 by Chronic Psychosocial Stress in the Tree Shrew
| Autor: | Flugge G, Jamieson Pm, Fuchs E, Seckl |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
endocrine system
medicine.medical_specialty animal structures biology Endocrine and Autonomic Systems Physiology Hippocampus Hippocampal formation Behavioral Neuroscience Psychiatry and Mental health chemistry.chemical_compound Neuropsychology and Physiological Psychology Endocrinology chemistry 11β-hydroxysteroid dehydrogenase type 1 Corticosterone Internal medicine medicine biology.protein Chronic stress Cortisone Receptor hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Stress. 2:123-131 |
| ISSN: | 1607-8888 1025-3890 |
| DOI: | 10.3109/10253899709014743 |
| Popis: | 11 P-hydroxy steroid dehydrogenase type 1 (11 P-HSD-1) catalyses the interconversion of active Cortisol and corticosterone with inert cortisone and 11-dehydrocorticosterone, thus regulating glucocorticoid access to intracellular receptors. In rats, chronic glucocorticoid excess or stress increases 11β-HSD-1 in the hippocampus, producing suggestions that it may attenuate the deleterious effects of chronic glucocorticoid excess. However, 11β-HSD-1 predominantly catalyses 11 P-reduction in the intact liver and hippocampal cells, thus regenerating active glucocorticoids from inert substrate. We studied 11β-HSD activity in the tissues of male tree shrews following 28 days of sustained psychosocial stress or exogenous administration of Cortisol. In the hippocampus, chronic psychosocial stress attenuated 11-HSD-l activity (69 ± 9% of control), whereas Cortisol alone had no effect. In the liver, both chronic stress and Cortisol administration decreased 11β-HSD-1 activity (47 ± 11% and 49 ± 4% fall, resp.). Attenu... |
| Databáze: | OpenAIRE |
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