Prognostic Value of CD45Ro+ T-Cell Expression in Patients With Oral Squamous Cell Carcinoma
| Autor: | Shota Shimizu, Akihiro Miyazaki, Kazuhiro Ogi, Kazushige Koike, Hiroyoshi Hiratsuka, Kei Tsuchihashi, Takanori Sasaki, Tadashi Hasegawa, Tomoko Sonoda, Koyo Nishiyama, Hironari Dehari, Takashi Sasaya |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
business.industry Proportional hazards model T cell Cancer hemic and immune systems chemical and pharmacologic phenomena General Medicine medicine.disease medicine.anatomical_structure Oncology Stroma Parenchyma medicine Cancer research Biomarker (medicine) Basal cell In patient business |
| Zdroj: | Anticancer Research. 41:4515-4522 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.15262 |
| Popis: | Background/aim The role of tumour-infiltrating CD45Ro+ T-cells in oral squamous cell carcinoma (OSCC) is unclear. This study aimed to evaluate prognostic biomarkers for OSCC. Patients and methods We determined the density of tumour-infiltrating CD45Ro+ T cells in the parenchyma and stroma at the tumour centre (TCe) and invasive front (IF) and examined the association between the density of these cells and histopathological status in 142 patients. Results Five-year overall survival (OS) and recurrence-free survival were favourable in patients with high CD45Ro+ T-cell density in the TCe stroma. OS was favourable in patients with high CD45Ro+ T-cell density in the IF stroma. Stepwise Cox regression model analysis indicated that CD45Ro+ T-cells in the stroma of the IF and TCe were an independent prognostic factor for OS. Conclusion CD45Ro+ T-cells in the stroma of the IF and TCe play a role in cancer immune surveillance and may be a useful prognostic factor. |
| Databáze: | OpenAIRE |
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