High Exchange Rate Complexes of 129 Xe with Water-Soluble Pillar[5]arenes for Adjustable Magnetization Transfer MRI
| Autor: | Leif Schröder, Dana Kaizerman-Kane, Roymon Joseph, Yoram Cohen, Alissa Naugolny-Keisar, Matthias Schnurr, Nils Bogdanoff, Patrick Schuenke |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Magnetization Transfer MRI Materials science Pillar 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Atomic and Molecular Physics and Optics 0104 chemical sciences Ion Water soluble chemistry Chemical physics Magnetization transfer Physical and Theoretical Chemistry Counterion 0210 nano-technology Biosensor Saturation (magnetic) |
| Zdroj: | ChemPhysChem. 20:246-251 |
| ISSN: | 1439-4235 |
| DOI: | 10.1002/cphc.201800618 |
| Popis: | Macrocyclic host structures for generating transiently bound 129 Xe have been used in various ultra-sensitive NMR and MRI applications for molecular sensing of biochemical analytes. They are based on hyperpolarized nuclei chemical exchange saturation transfer (Hyper-CEST). Here, we tested a set of water-soluble pillar[5]arenes with different counterions in order to compare their potential contrast agent abilities with that of cryptophane-A (CrA), the most widely used host for such purposes. The exchange of Xe with such compounds was found to be sensitive to the type of ions present in solution and can be used for switchable magnetization transfer (MT) contrast that arises from off-resonant pre-saturation. We demonstrate that the adjustable MT magnitude depends on the interplay of saturation parameters and found that the optimum MT contrast surpasses the CrA CEST performance at moderate saturation power. Since modification of such water-soluble pillar[5]arenes is straightforward, these compounds can be considered a promising platform for designing various sensors that may complement the field of Xe HyperCEST-based biosensing MRI. |
| Databáze: | OpenAIRE |
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