AB0057 ASSESSMENT OF MATRIX METALLOPEPTIDASE 3 (MMP3) AS A POTENTIAL BIOMARKER FOR RHEUMATOID ARTHRITIS IN ALGERIAN PATIENTS
| Autor: | Habiba Amroun, Dalila Fodil, H. Djoudi, Nabila Attal, S.S. Salah, M. Benidir |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
MMP3 education.field_of_study Metallopeptidase business.industry Cartilage Population Pannus Inflammation medicine.disease Connective tissue disease Gastroenterology medicine.anatomical_structure Internal medicine Rheumatoid arthritis medicine medicine.symptom business education |
| Zdroj: | Abstracts Accepted for Publication. |
| Popis: | Background: Matrix metallopeptidase 3 (MMP3) is a protease induced by rheumatoid pannus pro-inflammatory cytokines during rheumatoid arthritis (RA) and degrades many cartilage and bone components. Its serum level is a useful marker for predicting joint destruction and evaluating disease activity. Objectives: First, compare MMP3 production in RA patients to controls, then try to place this marker in the evaluation of disease activity. Methods: We subdivided the studied population into three groups: RA: n = 134; sex ratio: 1: 5; age: 50 ± 14 years; disease duration: 7 ± 9 years, Healthy controls: n = 67; sex ratio: 1: 7; age: 38 ± 11 years, Population control: Patients with: Inflammatory rheumatism: n = 80, Chronic inflammatory diseases (CID): 18 Connective tissue disease (CTD), 14 chronic hepatitis C and 2 Crohn disease (CD). The serum MMP3 measurement was performed by ELISA assay. Results: Serum MMP3 was significantly higher in RA patients vs. healthy controls (p Conclusion: MMP3 serum measurement is a particularly useful marker of inflammatory activity in RA and may have potential predictive value in the development of bone and joint destruction. References [1] Mahmood M. T. M. Ally, Bridget Hodkinson, Pieter W. A. Meyer, Eustasius Musenge, Mohammed Tikly, and Ronald Anderson. Hindawi Publishing Corporation. Mediators of Inflammation. Volume 2013, Article ID 183653, 6 pages [2] Fadda S, Abolkheir E, Afifi R, Gamal M. The Egyptian Rheumatologist. 2016;38(3):153-159. Disclosure of Interests: None declared |
| Databáze: | OpenAIRE |
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