T cell senescence and its correlation to inflammaging process of patients with systemic lupus erythematosus
| Autor: | Fahrina Ulfah, Hanani Octaviani, Kusworini Handono, Handono Kalim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
030203 arthritis & rheumatology
0301 basic medicine Senescence business.industry T cell CD28 hemic and immune systems chemical and pharmacologic phenomena Inflammation Correlation Pathogenesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure immune system diseases Immunology medicine medicine.symptom business Memory T cell CD8 |
| Zdroj: | INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND NANO-MEDICINE FROM NATURAL RESOURCES FOR BIOMEDICAL RESEARCH: 3rd Annual Scientific Meeting for Biomedical Sciences. |
| ISSN: | 0094-243X |
| Popis: | SLE patients suffered from morbidities resembled the natural aging process, suggesting chronic inflammation in SLE is correlated to premature immune senescence. However, understanding of immune senescence in SLE is not well established. The purpose of this study was to investigate the association of CD4+ and CD8+ T cells senescence markers of end differentiated T cell (CD28-), memory T cell (CD45RO+) and cytokines correlated to inflammaging (IL-2, and IFN-γ) among 61 SLE subjects aged 16-56 years. We measured the percentages of T cell senescence by flow cytometric analysis. Serum IL-2 and IFN-γ were measured by ELISA. Among 61 subjects, percentages of SLE subjects with increased senescence cells ranges from 3.2-58.3%. There was a positive correlation between the percentage of senescent T cells and serum IFN-γ (CD4+CD45RO+; p = 0.003, r = 0.453; CD8+CD45RO+; p = 0.045, r = 0.284; and CD4+CD28-; p = 0.029, r = 0.257) and negative correlation for the percentage of senescent T cells and serum IL-2 (CD4+CD28-; p = 0.014, r = −0384; CD8+CD28-; p = 0.012, r = −0394; CD4+CD45RO+; p = 0.023, r = −0.322; and CD8+CD45RO+; p = 0.017, r = −0.335). This study confirms the role of immune senescence in SLE pathogenesis, particularly in regard to the observed loss of CD28 and increased percentages of CD45RO expression from both CD8+ and CD4+ T cells. We also found the inflammaging process in SLE was correlated to T cell senescence. Studies of immune senescence might provide new opportunities for better understanding of SLE pathogenesis. |
| Databáze: | OpenAIRE |
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