Evaluation of antioxidant and anti-collagenase activity of Rosa damascena L. flower petal and receptacle extract
| Autor: | Ahmad Raif, Elfitriani Elfitriani, Refi Ikhtiari, Chrismis Novalinda Ginting |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Antioxidant General Immunology and Microbiology Traditional medicine biology medicine.medical_treatment General Medicine biology.organism_classification Antimicrobial 01 natural sciences General Biochemistry Genetics and Molecular Biology Terpenoid 0104 chemical sciences Terpene Rosa × damascena 010404 medicinal & biomolecular chemistry 03 medical and health sciences 030104 developmental biology chemistry Phytochemical medicine Tannin Petal General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | F1000Research. 9:716 |
| ISSN: | 2046-1402 |
| Popis: | Background: Rosa damascena L. is the most notable species of the Rosaceae family in the world, and has been used in food, cosmetics, and the pharmaceutical industry. Bioactive compounds in this flower are known to have several activities, such as antioxidant, antimicrobial, and anti-inflammatory. In this study, the antioxidant and collagenase inhibitory activities of R. damascena L. petal and receptacle extracts were evaluated. Methods: Ethanolic extraction of R. damascena L. petals (EERP) and R. damascena L. receptacles (EERR) were obtained, and bioactive compounds (flavonoids, phenolics, alkaloids, steroids, tannins, terpenoids, and triterpenoids) were classified by phytochemical screening. Antioxidant activities were analyzed by Ferric Reducing Antioxidant Power (FRAP) assay, while anti-collagenase analysis was examined through the inhibition of collagenase. Results: Phytochemical test revealed the presence of flavonoids, phenolics, alkaloids, steroids, triterpenoids, triterpenes, and tannin. EERP showed higher FRAP activity (164.23 ± 1.34 μM Fe(II)) than EERR (12.85 ± 6.19 μM Fe(II)). EERP also had higher inhibitory activity of collagenase (IC50 = 115.48±1.78 µM/mL) compared to EERR (IC50 = 141.96±6.13 µM/mL). Conclusions: R. damascena L. petal and receptacle ethanol extracts contain several components, such as phenolics, flavonoids, alkaloids, tannins, terpenes, triterpenoids, and steroids. These extracts exhibit antioxidant activity and collagenase inhibition. R. damascena L. petal extract showed higher antioxidant activity through FRAP assay and inhibitory activity of collagenase than R. damascena L. receptacle extract. |
| Databáze: | OpenAIRE |
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