The Role of Hyperhomocysteinemia in the Pathogenesis of Thromboocclusive Diseases

Autor: Nikita Vladimirovich Slysarenko, Alina Yuryevna Maslova, Natalia Yurievna Stepanova, KhavraAdamovna Dudugova, Omar Ruslanovich Gaidarbekov, Eldar Abdurahmanovich Saidov, Zaytun Said-Magomedovna Dikieva, Ibragim Abdulganievich Yusupov, Mubarik Dziyaudinovna Akaeva
Rok vydání: 2021
Předmět:
Zdroj: Journal of Pharmaceutical Research International. :130-136
ISSN: 2456-9119
DOI: 10.9734/jpri/2021/v33i48a33229
Popis: Homocysteine is a sulfur-containing non-proteinogenic amino acid that is an intermediate product of methionine metabolism. With excessive accumulation of homocysteine in the body, a state of hyperhomocysteinemia occurs, which has attracted the attention of doctors since the middle of the last century and received a serious impetus for research after the publication of data on the role of hyperhomocysteinemia in the pathogenesis of thromboocclusive diseases. To date, there are more than 7.5 thousand scientific papers devoted to the study of hyperhomocysteinemia, monothematic international conferences on clinical and therapeutic aspects of hypermonocysteinemia are held every year. In the Russian Federation, a detailed study of the role of homocysteine and its side effects in excess is of particular interest due to the prevalence of cardiovascular pathologies (according to statistics of the Ministry of Health of Russia-49.27% of deaths of Russians fall on this cohort of diseases). This is an important fact in Russian medicine, which deserves close attention from researchers and scientists.
Databáze: OpenAIRE
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