| Autor: |
Robert Jenq, Eiko Hayase, Tomo Hayase, Akash Mukherjee, Stuart Stinson, Mohamed Jamal, Miriam Ortega, Christopher Sanchez, Saira Ahmed, Jennifer Karmouch, Chia-Chi Chang, Ivonne Flores, Lauren McDaniel, Alexandria Brown, Rawan El-Himri, Valerie Chapa, Lin Tan, Bao Tran, Dung Pham, Taylor Halsey, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Israel Glover, Nadim Ajami, Jennifer Wargo, Samuel Shelburne, Pablo Okhuysen, Chen Liu, Stephanie Fowler, Margaret Conner, Christine Peterson, Gabriela Rondon, Jeffrey J Molldrem, Richard Champlin, Elizabeth Shpall, Philip Lorenzi, Rohtesh Mehta, Eric Martens, Amin Alousi |
| Rok vydání: |
2023 |
| DOI: |
10.21203/rs.3.rs-2460097/v1 |
| Popis: |
Acute gastrointestinal intestinal GVHD (aGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation, and the intestinal microbiota is known to impact on its severity. However, an association between treatment response of aGI-GVHD and the intestinal microbiota has not been well-studied. In a cohort of patients with aGI-GVHD (n=37), we found that non-response to standard therapy with corticosteroids was associated with prior treatment with carbapenem antibiotics and loss of Bacteroides ovatus from the microbiome. In a mouse model of carbapenem-aggravated GVHD, introducing Bacteroides ovatus reduced severity of GVHD and improved survival. Bacteroides ovatus reduced degradation of colonic mucus by another intestinal commensal, Bacteroides thetaiotaomicron, via its ability to metabolize dietary polysaccharides into monosaccharides, which then inhibit mucus degradation by Bacteroides thetaiotaomicron and reduce GVHD-related mortality. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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