Calorimetric and spectroscopic characterization of complexes between β-cyclodextrin or heptakis (2,6-di-O-methyl)-β-cyclodextrin and sertraline hydrochloride in aqueous solution
| Autor: | Vyacheslav Buko, I.B. Zavodnik, Sylwia Belica, D. Jeziorska, Pawel Urbaniak, Bartłomiej Pałecz |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution Cyclodextrin Enthalpy Analytical chemistry Isothermal titration calorimetry Atomic and Molecular Physics and Optics Sertraline Hydrochloride Gibbs free energy symbols.namesake chemistry Proton NMR symbols General Materials Science Titration Physical and Theoretical Chemistry Nuclear chemistry |
| Zdroj: | The Journal of Chemical Thermodynamics. 70:160-167 |
| ISSN: | 0021-9614 |
| DOI: | 10.1016/j.jct.2013.10.035 |
| Popis: | The interaction of sertraline hydrochloride (SRT) with β-cyclodextrin (β-CD) and heptakis(2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD) in aqueous solutions was investigated using the methods of isothermal titration calorimetry (ITC), nuclear magnetic resonance ( 1 H NMR) and UV–Vis spectroscopy. The interaction parameters, such as the association constant, enthalpy, entropy and Gibbs energy of complexation of SRT by β-CD and DM-β-CD in water at T = 298.15 K have been evaluated. Both enthalpic and entropic effects make a contribution to SRT association with β-CD or DM-β-CD. |
| Databáze: | OpenAIRE |
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