ChemInform Abstract: Asymmetric Synthesis of the mC7N Core of the Manumycin Family: Preparation of (+)-MT 35214 and a Formal Total Synthesis of (-)-Alisamycin

Autor:	Lilian Alcaraz, Gregor Macdonald, Lewis Norman John, Richard J. K. Taylor
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Cyclohexenone Central unit Enantioselective synthesis Epoxide Total synthesis Chiral phase General Medicine Alisamycin
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199843266
Popis:	An asymmetric approach to the mC7N epoxyquinone central unit of the manumycin antibiotics is described based on the enantioselective (89% ee) chiral phase transfer epoxidation of a substituted cyclohexenone. The chiral epoxide is employed in the first syntheses of the title compounds in enantiomerically pure form.
Databáze:	OpenAIRE
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