Synthesis and Blood-Compatibility of Poly(ethylene-g-γ-benzyl-L-glutamate)
| Autor: | Seong Wook Jang, Jum Sik Kim, Kea Yong Kim, Young Moo Lee, Yong Jun Lee |
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| Rok vydání: | 1991 |
| Předmět: | |
| Zdroj: | Polymer Journal. 23:259-266 |
| ISSN: | 1349-0540 0032-3896 |
| DOI: | 10.1295/polymj.23.259 |
| Popis: | A novel graft copolymer consisting of commercial chlorosulfonated polyethylene and γ-benzyl-L-glutamate was synthesized. The graft yield was over 70% at a mild reaction condition while we did not observe any crosslinking reaction. Polypeptide units were grafted into sulfonyl groups of the polyethylene. They formed an α-helical conformation as evidence by FT-IR, circular dichroism spectra, and wide angle X-ray diffraction patterns. The mechanical properties of copolymers showed that the Young’s modulus and the yield stress increased with peptide content in the polyethylene. The dynamic mechanical property showed that the side chain mobility was increasing due to incoporation of the peptide units.These affected the blood compatibility performance. The clotting time of the GP-4 and GP-5 samples was about 51 minutes. The platelet adhesion performance for the GP-4 and GP-5 samples was less than 5% as investigated by Coulter counter. Fibrin networks were not observed on the surface of GP-4 and GP-5 examined by SEM pictures. |
| Databáze: | OpenAIRE |
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