Insulin treatment increases skeletal muscle fibre area in patients with diabetes mellitus type 2
| Autor: | Christer Sylvén, Eva Jansson, M. Esbjörnsson-Liljedahl, T. Cederholm |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
biology Physiology Insulin medicine.medical_treatment Skeletal muscle medicine.disease chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Myoglobin Diabetes mellitus Lactate dehydrogenase Internal medicine biology.protein medicine Citrate synthase Creatine kinase Pancreatic hormone |
| Zdroj: | Clinical Physiology. 20:354-359 |
| ISSN: | 0144-5979 |
| Popis: | The effects of insulin treatment on skeletal muscle characteristics were studied in 18 patients (62 +/- 11 years) with poorly controlled diabetes mellitus type 2 (mean duration 7.5 +/- 6 years). Skeletal muscle biopsy samples were taken from the lateral portion of the quadriceps muscle before and after a period of insulin treatment of 40 +/- 14 days. Enzyme activities (phosphofructokinase, 3-hydroxyacyl-CoA dehydrogenase, citrate synthase, lactate dehydrogenase and creatine kinase) and myoglobin content were assessed. In a subgroup of 11 patients (60 +/- 11 years), skeletal muscle fibre type composition (type I, IIA, IIB and IIC) and fibre type cross-sectional area were also analysed. Following insulin treatment there were 32 and 38% increases, respectively, in the cross-sectional areas of type IIA and IIB fast-twitch fibres (P |
| Databáze: | OpenAIRE |
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