| Autor: |
Qiao Nan Guo, Yan Hui Liu, Xiao Peng Tian, Li Ye Zhong, Xi Zhang, Qiong Liang, Xia Gu, Fang Liu, Qiong Li Zhai, Kun Ru, Xiao-Dong Chen, Zhi Gang Zhu, Fen Zhang, Chun Kui Shao, Hui Zheng Bao, Zhihua Li, Cai Sun, Mei Li, Qi Sun, Xiao Liang Lan, Liang Wang, Shu Yun Ma, Wei Dong, Kun Yi, Li-Yan Song, Wei Sang, Hong Yi Gao, Xue Yi Pan, Wei Juan Huang, Qiong Lan Tang, Lu Liu, Hui Lan Rao, Hui Qiang Huang, Tong Yu Lin, Juan Li, Dan Xie, Hai Lan, Yong Zhu, Tie Bang Kang, Chang Lu Hu, Bing Liao, Yue Rong Shuang, Run Fen Cheng, Guo Wei Li, Yi Rong Jiang, Wen Jun He, Qing Qing Cai, Jun Rao, Ying Zhou, Zhong Jun Xia, Li Liang, Xi Na Lin, Xiang Ling Meng, Ying Zhang, Hui Liu |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Leukemia. 34:2392-2404 |
| ISSN: |
1476-5551
0887-6924 |
| Popis: |
We aimed to establish a discriminative gene-expression-based classifier to predict survival outcomes of T-cell lymphoblastic lymphoma (T-LBL) patients. After exploring global gene-expression profiles of progressive (n = 22) vs. progression-free (n = 28) T-LBL patients, 43 differentially expressed mRNAs were identified. Then an eleven-gene-based classifier was established using LASSO Cox regression based on NanoString quantification. In the training cohort (n = 169), high-risk patients stratified using the classifier had significantly lower progression-free survival (PFS: hazards ratio 4.123, 95% CI 2.565–6.628; p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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