Induction of Apoptosis of Endothelial Cells by Viscum album: A Role for Anti-Tumoral Properties of Mistletoe Lectins

Autor:	Srini V. Kaveri, Sandrine Delignat, Antonino Nicoletti, Odile Michel, Jean-Paul Duong Van Huyen, Anh Thu Gaston, Patrick Bruneval, Jagadeesh Bayry, Michel D. Kazatchkine
Rok vydání:	2002
Předmět:	Biology biology.organism_classification Molecular medicine Endothelial stem cell In vivo Cell culture Apoptosis Annexin Immunology Genetics Cancer research Viscum album Molecular Medicine Cytotoxic T cell Molecular Biology Genetics (clinical)
Zdroj:	Molecular Medicine. 8:600-606
ISSN:	1528-3658 1076-1551
Popis:	Background: Viscum album (VA) preparations consist of aqueous extracts of different types of lectins of VA. Mistletoe lectins have both cytotoxic and immunomodulatory properties that support their study for the development for cancer therapy. However, the mechanisms of the antitumoral properties in vivo of mistletoe lectins are not fully understood. Because endothelial cells (EC) play a pivotal role in tumor angiogenesis, we tested the hypothesis that VA extracts induce endothelial cell death and apoptosis. Material and Methods: We investigated the effect of various VA preparations on both human venous endothelial cell (HUVEC) and immortalized human venous endothelial cell line (IVEC) using morphologic assessment of EC, FACScan analysis after propidium iodine and annexin V
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::df1ad104ce27ca981c2a7a84f38c9f5f https://doi.org/10.1007/bf03402170 Zobrazit plný text záznamu Full text from SpringerLink