Brain 11 C‐ITMM PET to longitudinally assess type 1 metabotropic glutamate receptor availability in Alzheimer's disease
Autor: | Yoshiharu Miura, Kenji Ishibashi, Kei Wagatsuma, Masashi Kameyama, Kenji Ishii |
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Rok vydání: | 2021 |
Předmět: |
Temporal cortex
Cerebellum medicine.medical_specialty business.industry Posterior parietal cortex Hippocampus Binding potential 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Endocrinology Metabotropic glutamate receptor Internal medicine medicine Radioligand Metabotropic glutamate receptor 1 Radiology Nuclear Medicine and imaging Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | Journal of Neuroimaging. 31:864-868 |
ISSN: | 1552-6569 1051-2284 |
Popis: | Background and purpose Little evidence exists on the role of type 1 metabotropic glutamate receptor (mGluR1) in the pathophysiology of Alzheimer's disease (AD), although mGluR1 may be involved in the regulation of neuronal excitability and synaptic plasticity. We have recently reported that mGluR1 availability in the early stage of AD is equivalent to that in healthy subjects. This study aimed to address whether mGluR1 availability changes with the progression of AD. Methods Eight patients with AD (79.1 ± 4.6 years) underwent a total of two positron emission tomography (PET) examinations using the mGluR1 radioligand during the early-to-middle stages of AD. The mean interval was 2.8 years. Volumes-of-interest were placed on the frontal, parietal, and temporal cortices, hippocampus, anterior and posterior lobes, and vermis in the cerebellum. The binding potential (BPND ) was calculated to estimate mGluR1 availability, applying partial volume correction to the BPND values. Results No significant difference was observed in BPND values between the first and second PET examinations in the frontal cortex (p = 0.94), parietal cortex (p = 0.67), temporal cortex (p = 0.20), hippocampus (p = 0.17), anterior lobe (p = 0.73), posterior lobe (p = 0.21), and vermis (p = 0.22). Conclusion This study suggests that mGluR1 availability is unchanged in the follow-up period of a few years during the early-to-middle stages of AD. |
Databáze: | OpenAIRE |
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