Atypical Presentation of Herpes Simplex Virus Type 2 Infection Refractory to Treatment With Aciclovir in 2 Hematologic Patients
| Autor: | D. Nieto Rodríguez, J.M. Rueda Carnero, P. Herranz Pinto, E. Sendagorta Cudós |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Foscarnet medicine.medical_specialty Histology 030106 microbiology Imiquimod Dermatology medicine.disease_cause Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Refractory medicine 030212 general & internal medicine Aciclovir business.industry virus diseases medicine.disease Lymphoma Leukemia Herpes simplex virus chemistry business medicine.drug Cidofovir |
| Zdroj: | Actas Dermo-Sifiliográficas (English Edition). 110:393-397 |
| ISSN: | 1578-2190 |
| DOI: | 10.1016/j.adengl.2019.04.005 |
| Popis: | Herpesvirus infections are not uncommon in hematologic patients. Our first patient, diagnosed with chronic lymphatic leukemia, presented extensive genital herpes infection refractory to treatment with aciclovir and with a partial response to foscarnet, which had to be withdrawn due to systemic adverse effects. The second patient, diagnosed with follicular Hodgkin lymphoma, presented hypertrophic herpes infection refractory to treatment with aciclovir but that responded to intralesional cidofovir and topical imiquimod. As in other immunocompromised patients, herpesvirus infection in hematologic patients can present atypical manifestations, as well as resistance to treatments that are activated by the viral thymidine kinase. A high level of clinical suspicion is therefore needed to make an early diagnosis, together with extensive knowledge of the different treatments available. |
| Databáze: | OpenAIRE |
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