Effect of dihydroxyacetophenone on pulmonary hemodynamics and atrial natriuretic peptide as well as adenosine cyclophosphates level in patients of chronic obstructive pulmonary disease

Autor: Chun-Long Lin, Zhen-xiang Zhang, Yong-jian Xu, Wang Ni
Rok vydání: 1996
Předmět:
Zdroj: Chinese Journal of Integrative Medicine. 2:166-169
ISSN: 1672-0415
DOI: 10.1007/bf02934239
Popis: In order to study the effect of dihydroxyacetophenone (DHAP) on pulmonary hemodynamics and its relationship to plasma atrial natriuretic peptide (ANP) as well as adenosine cyclophosphates in chronic obstractive pulmonary disease (COPD), right heart catheterization was used to examine some parameters of hemodynamics in 11 COPD patients before and after the application of DHAP, and at the same time radioimmunoassay was used to measure the plasma ANP and cyclo-adenosine monophosphate/cyclic guanosine monophosphate (cAMP/cGMP). The results showed that DHAP 640 mg given intravenously could decrease mean pulmonary arterial pressure, pulmonary vascular resistance and systemic vascular resistance (P 0.05) and without affecting systemic arterial blood pressure (P>0. 05) as well as blood gas analysis; it could also reduce the plasma ANP and cGMP level from 0.73 ± 0.42 pg/ml to 0.41 ±0.33 pg/ml (P 0.05). It is suggested that DHAP may relax pulmonary vessels by adjusting the ratio of cAMP to cGMP, and the lowering of plasma ANP level might be a secondary reaction. So DHAP was considered a quick-acting, safe and potential drug in treating pulmonary arterial hypertension by COPD.
Databáze: OpenAIRE
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