Synthesis and studies on gem-fluorinated 2-azabicyclo[n.1.0]alkanes

Autor:	Pavel K. Mykhailiuk, Vladimir Kubyshkin, Yurii Kheylik
Rok vydání:	2015
Předmět:	Inorganic Chemistry Acylation chemistry.chemical_compound Fragmentation (mass spectrometry) Chemistry Chemical structure Organic Chemistry Environmental Chemistry Organic chemistry Protonation Physical and Theoretical Chemistry Biochemistry Cyclopropane
Zdroj:	Journal of Fluorine Chemistry. 175:73-83
ISSN:	0022-1139
DOI:	10.1016/j.jfluchem.2015.03.008
Popis:	Three novel amines all possessing gem-difluorocyclopropane, secondary amino group and a fused aliphatic cycle were synthesized by difluorocyclopropanation of N-Boc protected enamides. The compounds were stable when amino group was blocked by protonation or acylation, but otherwise underwent fragmentation already at the room temperature. Chemical structure, physico-chemical properties and fragmentation mechanisms of the fluorinated amines are studied in details.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::df13945d65874f96904054efb1b15411 https://doi.org/10.1016/j.jfluchem.2015.03.008 Zobrazit plný text záznamu Full Text from ScienceDirect