sGC Stimulation Results in Potent Anti‐hypertensive Effects as a Stand‐alone or Combination Therapy in the Rat

Autor:	Joel D. Moore, Kristie Sykes, Peter Germano, Kimberly Long, Jenny Tobin, Jaime L. Masferrer, Robert Jefferson, Erik Solberg, James E. Sheppeck, Takashi Nakai, Samuel Rivers, Courtney Shea, James Wakefield
Rok vydání:	2015
Předmět:	inorganic chemicals Combination therapy Stimulation Pharmacology Biochemistry Nitric oxide chemistry.chemical_compound chemistry Guanosine monophosphate cardiovascular system Genetics heterocyclic compounds Molecular Biology Ironwood Biotechnology Guanylate cyclase
Zdroj:	The FASEB Journal. 29
ISSN:	1530-6860 0892-6638
DOI:	10.1096/fasebj.29.1_supplement.623.5
Popis:	Soluble guanylate cyclase (sGC) stimulators have the potential to treat a variety of cardiovascular diseases via the nitric oxide (NO)-sGC-cyclic guanosine monophosphate (cGMP) pathway. Ironwood Ph...
Databáze:	OpenAIRE
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