Sodium Alginate Interpolymer Complexes as a Platform for pH-Tunable Drug Carriers
| Autor: | M. Yu. Gorshkova, I. F. Volkova, Valuev Lev I, E. S. Grigoryan |
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| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Hydrogen bond Maleic anhydride 02 engineering and technology Methyl vinyl ether 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Polymer chemistry Drug delivery Self-healing hydrogels Materials Chemistry Ceramics and Composites Copolymer Polymer blend 0210 nano-technology Drug carrier |
| Zdroj: | Polymer Science, Series B. 62:678-684 |
| ISSN: | 1555-6123 1560-0904 |
| Popis: | The method of obtaining hydrogels from sodium alginate interpolymer complexes with the copolymer of methyl vinyl ether and maleic anhydride is developed. It is shown that the interpolymer network is formed via hydrogen bonding between the hydroxyl groups of alginate and the carboxyl groups of the copolymer. The structure of the network, namely, the type of bonds and their density, is primarily controlled by the treatment temperature of the polymer mixture. Using lidocaine as a model drug, it is demonstrated that these complexes can be used as a platform for рН-tunable drug delivery systems. |
| Databáze: | OpenAIRE |
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