The synthesis and activity of spiroindane growth hormone secretagogues
| Autor: | Bridget Butler, Wanda W.-S. Chan, Liente Wei, Roy G. Smith, Marcia M. Murphy, Arthur A. Patchett, Kang Cheng, Gerard J. Hickey, Thomas M. Jacks, Ravi P. Nargund, David B. R. Johnston, James R. Tata |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Dipeptide Peptidomimetic Organic Chemistry Clinical Biochemistry Pharmaceutical Science Peptide Growth hormone Biochemistry Chemical synthesis In vitro chemistry.chemical_compound Endocrinology chemistry In vivo Internal medicine Drug Discovery medicine Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 7:663-668 |
| ISSN: | 0960-894X |
| Popis: | The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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