Sample sizes for cancer therapy survival studies based on response surface methods

Autor:	Walter H. Carter, Janis L. Goodlow, Donald M. Stablein
Rok vydání:	1987
Předmět:	Statistics and Probability Applied Mathematics Cancer therapy Confidence interval Design characteristics Quadratic equation Drug activity Sample size determination Modeling and Simulation Censoring (clinical trials) Statistics Statistical analysis Statistics Probability and Uncertainty Mathematics
Zdroj:	Journal of Statistical Computation and Simulation. 28:31-41
ISSN:	1563-5163 0094-9655
Popis:	Sample size characteristics for the performance of time to event response surface studies are determined where both proportional hazards and quadratic surfaces apply. Single drug activity is evaluated through the use of confidence intervals and computer simulations are employed to assess design characteristics including optimum location, grouping and censoring. Confidence intervals can be reliably constructed for the smallest sample size considered (n=48). Power considerations applicable to pre clinical studies are presented with discussion of extensions including clinical applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::defc29e4a66be748b2f470547ff65a69 https://doi.org/10.1080/00949658708811006 Zobrazit plný text záznamu