VALPROATE-INDUCED HYPERAMMONEMIC ENCEPHALOPATHY IN A CHILD WITHOUT HEPATIC FAILURE: A CASE REPORT

Autor:	Chennadi Amith Kumar, Sai Chandar Dudipala, Prashanthi Mandapuram
Rok vydání:	2020
Předmět:	Polypharmacy Valproic Acid Pediatrics medicine.medical_specialty business.industry Encephalopathy Plasma levels medicine.disease Epilepsy in children Urea cycle medicine lipids (amino acids peptides and proteins) Hyperammonemic encephalopathy Complication business medicine.drug
Zdroj:	Indian Journal of Case Reports. :112-113
ISSN:	2454-1303 2454-129X
Popis:	Sodium valproate or valproic acid (VPA) is an effective antiepileptic drug that is commonly used for epilepsy in children because of its broad-spectrum activity. The use of VPA frequently results in elevated plasma levels of ammonia with or without raised transaminases. This condition usually happens when VPA with polypharmacy or underlying metabolic disorders like urea cycle defects. We are reporting a case of valproate-induced hyperammonemic encephalopathy in a child which is rare in children. Health professionals should be aware of this potential complication, and it is highly recommended to check ammonia levels in patients taking VPA who present with a change in mental status. If identified early, it can treat with appropriate measures and it can reversible.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::def7fd2916c9a9f67f4f627b50e182fd https://doi.org/10.32677/ijcr.2020.v06.i03.005 Zobrazit plný text záznamu