The regulatory influence of galarmin on the level and activity of rat tissue metalloproteins after doxorubicin-induced nephro- and cardiotoxicity

Autor:	G. A. Kevorkian, L. H. Tadevosyan, Armen A. Galoyan, M. A. Simonyan, L. N. Arakelyan
Rok vydání:	2011
Předmět:	Mammary tumor Cardiotoxicity biology Chemistry Cytochrome c Mitochondrion Pharmacology medicine.disease Biochemistry Nephrotoxicity Cellular and Molecular Neuroscience Leukemia Pancreatic tumor medicine biology.protein Doxorubicin Molecular Biology medicine.drug
Zdroj:	Neurochemical Journal. 5:215-219
ISSN:	1819-7132 1819-7124
Popis:	Doxorubicin (DR) is a potential antineoplastic drug that is used for therapy of different types of malignant tumors (leukemia, lymphoma, mammary tumor, lung, ovarian, pancreatic tumor etc.). However, the long-term use of DR leads to irreversible cardiomyopathy and nephropathy due to DR-induced formation of free oxygen radicals that disturb the functionality of the mitochondria, membranes, and nuclei of cells. The mechanisms of DR-induced cardiotoxicity and nephrotoxicity associated with changes in the activity of antioxidant metalloproteins (Cu, Zn-SOD, Mn-SOD, and catalase) and prooxidant metalloproteins (acidic isoforms of cytochrome (cyt) b558 and cyt C) in heart and kidney cells are not clear. Here we tried to evaluate these biochemical factors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::def4cf8c7433e8dea5de7548dbf8939f https://doi.org/10.1134/s1819712411030123 Zobrazit plný text záznamu Full text from SpringerLink