Nongerminomatous Germ Cell Tumor of the Pineal Gland Causing Gonadotropin-Independent Precocious Puberty in a Child With 47, XYY Karyotype
| Autor: | Asjad Khan, Moris Angulo, Donald Price, J. Atilio Canas, Mariano Castro-Magana |
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| Rok vydání: | 2004 |
| Předmět: |
endocrine system
medicine.medical_specialty business.industry medicine.drug_class Endocrinology Diabetes and Metabolism medicine.disease Gonadotropin-Independent Precocious Puberty Pineal gland medicine.anatomical_structure Endocrinology Internal medicine XYY Karyotype Medicine Precocious puberty Gonadotropin business Luteinizing hormone Germ cell Testosterone |
| Zdroj: | The Endocrinologist. 14:261-264 |
| ISSN: | 1051-2144 |
| DOI: | 10.1097/01.ten.0000139000.64137.60 |
| Popis: | A 3-year and 11-months-old boy presented with a 9-month history of increasing penile enlargement, pubic hair, deepening of the voice, and rapid growth. The erect penile length was 14 cm with bilateral testicular volume of 3 mL. Laboratory evaluation revealed suppressed follicle-stimulating hormone and luteinizing hormone, elevated total testosterone (259 ng/dL), elevated alpha feto-protein (AFP 79 ng/mL), rapidly increasing β-human chorionic gonadotropin (β-hCG 14–399 mIU/mL) over 2 weeks, and a karyotype revealed 47, XYY. Radiographic evaluation revealed a 1.5-cm mixed solid/cystic mass in the pineal gland. Chemotherapy was initiated to attempt to normalize the tumor markers (AFP and β-hCG). This is the first report of a nongerminomatous germ cell tumor (NGGCT) in a 47, XYY karyotype male. Tumor markers (hCG and AFP) should be included in the workup of adult males with 47, XYY as they are in children with precocious puberty. |
| Databáze: | OpenAIRE |
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