One step amidine formation via reductive cyclization of (2-pyridyl)-β-nitriles
| Autor: | Renata Siedlecka, Rafał Wal, Jacek Skarżewski |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
inorganic chemicals
Nitrile 010405 organic chemistry Organic Chemistry chemistry.chemical_element One-Step 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Partial hydrogenation Amidine chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Pyridine Organic chemistry Palladium |
| Zdroj: | Tetrahedron. 72:6678-6683 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2016.08.090 |
| Popis: | New cyclic amidines are obtained in a one-step procedure by the palladium-catalyzed reduction of (2-pyridyl)-β-nitriles. The partial hydrogenation of pyridine derivatives takes place under acidic conditions, followed by spontaneous ring closure promoted by palladium activation of the nitrile. The reaction is highly efficient (80–91% yield) and occurs under mild conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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