84 Does Dual-Task Gait Speed Predict Cognitive Performance in Midlife Type 2 Diabetes? Baseline Results from the ENBIND Study
| Autor: | Conor Woods, Adam H Dyer, Nollaig M. Bourke, Desmond O'Neill, Richard B. Reilly, Isabelle Killane, James Gibney, Sean Kennelly |
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| Rok vydání: | 2019 |
| Předmět: |
Aging
medicine.medical_specialty business.industry Montreal Cognitive Assessment Cognition General Medicine Type 2 diabetes medicine.disease Task (project management) Preferred walking speed Physical medicine and rehabilitation Gait (human) Medicine Dementia Effects of sleep deprivation on cognitive performance Geriatrics and Gerontology business |
| Zdroj: | Age and Ageing. 48:iii1-iii16 |
| ISSN: | 1468-2834 0002-0729 |
| Popis: | Background Type 2 Diabetes (T2DM) in midlife is associated with a greater risk of dementia in later life. The longitudinal ENBIND Study is examining novel approaches to biomarker discovery in this high-risk group which may help identify those at greatest risk Methods Non-demented participants with midlife T2DM (no micro/macrovascular complications) and matched controls were recruited. Following detailed health/diabetes assessment, general cognitive (MoCA) and computerised neuropsychological (CANTAB) assessment were performed. Gait was assessed by stopwatch and accelerometers across several tasks including self-selected and maximal gait speed in addition to a dual-task cognitive paradigm (reciting alternate letters of the alphabet). Bloods were analysed for C-Reactive Protein (CRP) and glycated haemoglobin (HbA1c). Between group differences were analysed using t-tests/non-parametric equivalents and linear regression used for multivariate analysis. Results Sixty participants with T2DM (51.9 +/- 8.4 yrs) and 30 matched controls (52.3 +/- 7.9 yrs) were recruited. Controlling for demographic and cardiovascular covariates, T2DM was associated with a lower MoCA score, slower self-selected, maximal and dual-task gait speed (all p Conclusion Midlife T2DM is associated with poorer cognitive performance. Gait speed, and in particular dual-task gait speed, correlate strongly with general cognitive performance. Future work will tease out the specific domains of gait and cognition which are affected, and assess longitudinally in this high-risk group. |
| Databáze: | OpenAIRE |
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