ChemInform Abstract: A Practical Synthesis of Novel Rho-Kinase Inhibitor, (S)-4-Fluoro-5-(2-methyl-1,4-diazepan-1-ylsulfonyl)isoquinoline

Autor:	Jyunji Katsuyama, Tadaaki Ohgiya, Hitoshi Sakai, Kimiyuki Shibuya, Masayuki Masumoto, Noriaki Gomi
Rok vydání:	2011
Předmět:	chemistry.chemical_compound chemistry Rho kinase inhibitor Stereochemistry Moiety Regioselectivity General Medicine Isoquinoline Combinatorial chemistry
Zdroj:	ChemInform. 42
ISSN:	0931-7597
DOI:	10.1002/chin.201148185
Popis:	The synthesis of the novel inhibitor (VII) is achieved in multi-kilogram scale overcoming two major issues: the need of developing a regioselective chlorosulfonylation reaction at C-5 of fluoroisoquinoline and the stereochemical purity in the asymmetric construction of the methyldiazepane moiety.
Databáze:	OpenAIRE
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