Apparent modulation of CD20 by rituximab: an alternative explanation
| Autor: | Thomas Valerius, Peter Johnson, Martin J. Glennie, Mike Bayne, Timothy M Illidge, Mark S. Cragg |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD20
biology business.industry medicine.drug_class media_common.quotation_subject Immunology Cell Biology Hematology Monoclonal antibody Biochemistry Rna regulation immune system diseases hemic and lymphatic diseases biology.protein Cancer research Medicine Rituximab business Internalization media_common medicine.drug |
| Zdroj: | Blood. 103:3989-3991 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | We read with interest the paper from Jilani et al[1][1] in which rituximab treatment appeared to down-modulate CD20 expression through a combination of internalization and RNA regulation. The result is unexpected because previous studies had shown that CD20 is not modulated by monoclonal antibody ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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