Post Traumatic Fibrous Dysplasia of Ribs at the Chest Tube Site (A Case Report)
| Autor: | Azam Mardani, Seyed Hamzeh Mousavie, Vahid Abbasnejad, Alireza Moradi, Amirhossien Arminfard, Behnood Farazmand, Parisa Hosseinpor |
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| Rok vydání: | 2019 |
| Předmět: |
Rib cage
Mutation Pathology medicine.medical_specialty biology Health Toxicology and Mutagenesis Fibrous dysplasia Toxicology medicine.disease medicine.disease_cause Pathology and Forensic Medicine Lesion Skeletal disorder medicine Etiology GNAS complex locus biology.protein medicine.symptom Law G alpha subunit |
| Zdroj: | Indian Journal of Forensic Medicine & Toxicology. 13:257 |
| ISSN: | 0973-9130 0973-9122 |
| Popis: | Fibrous Dysplasia (FD) is a benign non-inherited and rare skeletal disorder that can affect any bone of human body. FD is caused by a mutation in GNAS1 gene, but the mutation is not inherited from parents. While there are some reports of post-traumatic fibrous dysplasia, but the relationship between fibrous dysplasia and trauma or previous injury is unclear. Most of the time, fibrous dysplasia is diagnosed by accident in x-ray imaging. While there is much information on fibrous dysplasia, the main etiology is still unknown, however it seems to be linked to a gene mutation. A mutation in this gene affects differentiation and proliferation of cells. This benign fibro-osseous lesion is a result of disturbances of normal bone metabolism by a mutation of the alpha subunit of guanine nucleotide binding protein alpha stimulating. Here we report a case with two adjacent ribs involvement in a 25-year old man who admitted to our hospital with an acute right chest pain and swelling with history of major trauma in a motor vehicle accident 4 years ago with associated hemo-pneumothorax resulted in thoracostomy tube insertion and with subcutaneous mass was detected in the right chest wall which was located exactly at the thoracostomy tube insertion site. |
| Databáze: | OpenAIRE |
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