Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 13. Design, synthesis and biological evaluation of tetrazole anilides as potent inhibitors of ACAT in vitro and hypocholesterolemic agents in vivo

Autor:	Timothy R. Hurley, R. L. Stanfield, Maureen K. Anderson, Brian R. Krause, Drago Robert Sliskovic, Adele Bernabei, Patrick Michael O'brien, R. F. Bousley
Rok vydání:	1995
Předmět:	Stereochemistry Cholesterol Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Acyl transferase In vitro chemistry.chemical_compound Acyl-CoA Acetic acid Design synthesis chemistry In vivo Drug Discovery Molecular Medicine Tetrazole Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:295-300
ISSN:	0960-894X
Popis:	The syntheses and biological activities for anilides derived from 2-phenyl-2-(dodecyl-2H-tetrazol-5-yl)acetic acid are described. Evidence is provided that one of these compounds, (+)- 8b , stereoselectively inhibits ACAT in vitro and possesses superior efficacy in vivo compared to (−)- 8b or the recemic mixture (±)- 8b .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::deab38b81f1f99ae2d7f0c27e165ac6d https://doi.org/10.1016/0960-894x(95)00025-o Zobrazit plný text záznamu Full Text from ScienceDirect