Dynorphin interaction with the NMDA receptor/channel complex:Correlation with spinal cord injury
| Autor: | J.C. Hunter, S. Purbrick, Geoffrey N. Woodruff, P.R. Boden |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Physiology Chemistry Clinical Biochemistry Central nervous system Neuropeptide Dynorphin A Dynorphin medicine.disease Spinal cord Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology medicine.anatomical_structure Internal medicine medicine NMDA receptor Opioid peptide Spinal cord injury |
| Zdroj: | Regulatory Peptides. 53:S89-S90 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/0167-0115(94)90255-0 |
| Popis: | Dynorphin A and related peptides have been implicated in the neuropathology of spinal cord injury by a mechanism that may involve an interaction with the NMDA receptor-channel complex. Using radioligand binding and electrophysiological techniques, the present study has investigated the possible post-synaptic interaction between dynorphin (dyn) peptides and the MK-801 related channel site of the NMDA complex in rat brain and spinal cord. Dyn fragments (0.01-10 μM) produced a partial inhibition (45-75%) of [ 3 H]MK-801 binding to cerebral cortex membranes with slope values significantly greater than unity (-1.2 to -2.2) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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