Model-based process analysis of heterotrophic-autotrophic poly(3-hydroxybutyrate) (PHB) production
| Autor: | Linsey Garcia-Gonzalez, Eveline Volcke, Md. Salatul Islam Mozumder, Heleen De Wever |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0106 biological sciences
0301 basic medicine Environmental Engineering Waste management Chemistry Biomedical Engineering Heterotroph Biomass Bioengineering 01 natural sciences Bioplastic Polyhydroxyalkanoates 03 medical and health sciences 030104 developmental biology Chemical engineering 010608 biotechnology Scientific method Fermentation Limiting oxygen concentration Autotroph Biotechnology |
| Zdroj: | Biochemical Engineering Journal. 114:202-208 |
| ISSN: | 1369-703X |
| Popis: | Heterotrophic-autotrophic poly(3-hydroxybutyrate) (PHB) production is a promising process to produce bioplastics from CO2, which is more sustainable and safe compared to completely heterotrophic or completely autotrophic alternatives, respectively. In this study, pure culture heterotrophic-autotrophic PHB production was described through a mathematical model, which was validated on experimental datasets obtained with different organic substrates and applying different switching points from growth phase to PHB production phase. The mathematical model provided an accurate prediction of the dynamic behaviour of heterotrophic biomass growth and autotrophic PHB production. The model was subsequently applied for scenario analysis, to determine the optimal operation conditions in terms of O2 and NH4+-N concentrations in the fermentation medium. The optimal scenario for maximal PHB production was 0.224 mg/L oxygen concentration at ammonium-nitrogen (NH4+-N) free condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect