Insulin and adrenalin effects on the activity and concentration of glutathione metabolizing enzymes in rat organs
| Autor: | L. S. Kolesnichenko, M. V. Yasko, V. I. Kulinsky, Yu. V. Grudinina, G. A. Pensionerova |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Chemistry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Glutathione peroxidase Glutathione reductase Spleen Glutathione Hypoglycemia medicine.disease chemistry.chemical_compound medicine.anatomical_structure Enzyme Endocrinology Internal medicine medicine Transferase |
| Zdroj: | Problems of Endocrinology. 40:42-44 |
| ISSN: | 2308-1430 0375-9660 |
| Popis: | Adrenaline activates glutathione peroxidase in the heart, liver, and kidneys and glutathione transferase in the heart and liver, inhibits gamma-glutamyl transferase in the kidneys, and has no effect on glutathione reductase; no changes in the brain detected. Insulin does not influence glutathione reductase either, nor does it induce any changes in the heart, liver, and bone marrow, but it alters (as a rule reduces) in a number of cases the activities of many glutathione metabolism enzymes and reduces glutathione concentration in the brain, kidneys, and spleen both an hour and 24 h after injection. The detected changes do not conform to universally acknowledged classification of the organs by insulin sensitivity and do not correlate with hypoglycemia. |
| Databáze: | OpenAIRE |
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