AZT binding to DNA and RNA: Molecular modeling and biological significance

Autor:	H. A. Tajmir-Riahi
Rok vydání:	2005
Předmět:	Drug Molecular model media_common.quotation_subject RNA General Chemistry Molecular biology Binding constant chemistry.chemical_compound chemistry Biochemistry Biological significance Nucleic acid Binding site DNA media_common
Zdroj:	Journal of the Iranian Chemical Society. 2:78-84
ISSN:	1735-2428 1735-207X
Popis:	In this review we report the application of molecular modeling based on different analytical methods to locate the binding sites of anti-AIDS drug azidothymidine (AZT) in the major and minor grooves of DNA and RNA duplexes. The effects of drug complexation on nucleic acids secondary structures and the biological implication are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dea3335013e49ae2825287eb67767ad4 https://doi.org/10.1007/bf03247200 Zobrazit plný text záznamu Full text from SpringerLink