Methionine Gamma Lyase from Clostridium sporogenes Increases the Anticancer Efficacy of Doxorubicin on A549 Cancer Cells In Vitro and Human Cancer Xenografts
| Autor: | V. Y. Kotova, Gennadii B. Zavilgelsky, Vadim S. Pokrovsky, Ilya V. Manukhov, Sergey V. Bazhenov, N. Yu. Anisimova, N. V. Bulushova, D. Zh. Davydov |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Methionine biology Methionine gamma-lyase Clostridium sporogenes biology.organism_classification In vitro 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry In vivo 030220 oncology & carcinogenesis Cancer cell medicine Cancer research Doxorubicin Growth inhibition medicine.drug |
| Zdroj: | Methods in Molecular Biology ISBN: 9781493987955 |
| DOI: | 10.1007/978-1-4939-8796-2_18 |
| Popis: | The anticancer efficacy of methionine γ-lyase (MGL) from Clostridium sporogenes (C. sporogenes) is described. MGL was active against cancer cells in vitro and in vivo. Doxorubicin (DOX) and MGL were more effective on A549 human lung-cancer growth inhibition than either agent alone in vitro and in vivo. |
| Databáze: | OpenAIRE |
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