Study on Use of Antisecretory Drugs following Treatment with Calcium Channel Blockers among Non-elderly Patients in Community Pharmacies
| Autor: | Mitsuhiro Wada, Akihiro Hamada, Kenichiro Nakashima, Choichiro Miyazaki, Yuichi Ohwaki, Rie Ikeda, Ryuji Akiyoshi, Noriko Hamada, Tetsuya Hamada, Jun Ishii |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 37:203-208 |
| ISSN: | 1882-1499 1346-342X |
| DOI: | 10.5649/jjphcs.37.203 |
| Popis: | Calcium channel blockers (CCBs) decrease lower esophageal sphincter pressure,which may result in gastrointestinal disease.In a previous study,we observed an increased risk of gastrointestinal disease following treatment with CCBs in elderly patients.However,there have been few epidemiological studies in non-elderly patients to determine whether CCBs increase the risk of gastrointestinal disease.We hypothesized that there would be greater use of antisecretory drugs,such as H2-receptor antagonists and proton pump inhibitors (PPIs),among patients prescribed CCBs and to test this hypothesis,performed a dynamic retrospective cohort study from September 2005 to August 2008 at six community pharmacies in Nagasaki Prefecture,targeting patients aged< 55 y.Correlations between initiation of treatment with antisecretory drugs and maintenance therapy with PPIs were determined by the Cox proportional hazards model.The study included 86 patients on CCBs and 93 controls not on them.During the study period,12 patients on CCBs and 6 controls started to use antisecretory drugs,for which the hazard ratio was 4.02 (95% confidence interval 1.82-10.10,P |
| Databáze: | OpenAIRE |
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