Determinants of Hydroxychloroquine Blood Concentration Variations in Systemic Lupus Erythematosus

Autor:	Judith Cohen-Bittan, Xavier Mariette, Hélène Desmurs-Clavel, Lionel Galicier, Gaëlle Leroux, Moez Jallouli, Z. Amoura, Jean-Sébastien Hulot, V. Le Guern, Nathalie Costedoat-Chalumeau, D. Le Thi Huong, Amar Smail, Thomas Papo, Jérôme Stirnemann, Nicolas Limal, J.C. Piette, Camille Francès, Bouchra Asli, Frédéric Lioté, Jérémie Sellam, Olivier Fain, J.-E. Kahn, Karim Sacre, N. Zahr, F. Ackermann, Patrice Cacoub, O. Aumaître, Jacques Pourrat, Laurent Perard, Laurent Sailler, Benoit Blanchet
Rok vydání:	2015
Předmět:	030203 arthritis & rheumatology Lupus erythematosus Systemic blood business.industry Immunology Hydroxychloroquine Pharmacology medicine.disease 3. Good health 03 medical and health sciences 0302 clinical medicine Rheumatology Blood concentration Pharmacokinetics Pharmacodynamics Immunology and Allergy Medicine 030212 general & internal medicine Creatinine blood skin and connective tissue diseases business Body mass index medicine.drug
Zdroj:	Arthritis & Rheumatology. 67:2176-2184
ISSN:	2326-5191
DOI:	10.1002/art.39194
Popis:	Blood concentrations of hydroxychloroquine (HCQ) vary widely among patients with systemic lupus erythematosus (SLE). A pharmacokinetic/pharmacodynamic relationship has been found in different situations, and a very low blood concentration of HCQ is a simple marker of nonadherence to treatment. Therefore, interest in blood HCQ concentration measurement has increased, but little is known about factors that influence blood HCQ concentration variability. This study was undertaken to analyze determinants of blood HCQ concentrations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::de8b583fe4e22360c7a1460a7a27024c https://doi.org/10.1002/art.39194 Zobrazit plný text záznamu Plný text