Conformationally constrained HIV-1 protease inhibitors
| Autor: | P.M.D. Fitzgerald, Joel R. Huff, Ken E. Starbuck, L.J. Chen, Hungate Randall W, Paul L. Darke, P. S. Anderson, M. K. Holloway, J. P. Vacca |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
Protease biology Stereochemistry medicine.medical_treatment Organic Chemistry Clinical Biochemistry Human immunodeficiency virus (HIV) Pharmaceutical Science medicine.disease_cause Biochemistry Protease inhibitor (biology) Enzyme chemistry HIV-1 protease Enzyme inhibitor Drug Discovery biology.protein medicine Molecular Medicine Molecular Biology medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:499-504 |
| ISSN: | 0960-894X |
| Popis: | The synsthesis and structure activity relationships of conformationally constrained analogs of the HIV-1 protease inhibitor L-685,434 are described. In addition, the X-ray crystal structure of a complex between L-700,497 and the HIV-1 protease is shown. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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