Synthesis of DL-2-amino-3-(1,2-dihydro-2-thio-quinolinyl)propionic acid

Autor:	Ben-Zhi Qiao, Shi-Ying Jia, Ai-Xiu Li
Rok vydání:	2002
Předmět:	chemistry.chemical_classification Chemistry Propionate Nucleophilic substitution Thio chemistry.chemical_element Medicinal chemistry Sulfur
Zdroj:	Peptides Biology and Chemistry ISBN: 9780792349631
DOI:	10.1007/0-306-46859-x_64
Popis:	DL-2-amino-3-( 1,2-dihydro-2-oxo-quinolinyl) propionic acid (Aoq) have been synthesized [ 1,2] and resolved [2]. The physiological activities of DL-, Dand L-Aoq have been reported [2, 3]. In order to study the physiological activities of its sulfur substituted analogue-Atq, ethyl DL-2-acetylamino-3-( 1,2-dihydro-2-thio-quinoIinyl) propionate (I) as a precursor of Atq should be synthesized via selective thionation of ethyl 2-acetylamino-3(1,2-dihydro-2-oxo-quinolinyl) propionate (11).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::de72b202009ed53e7dbfbb2dd0300746 https://doi.org/10.1007/0-306-46859-x_64 Zobrazit plný text záznamu