Zn/ZnBr2 Catalysed Reaction of Aldehydes with Allylbromide: Synthesis of 2,6-Disubstituted 4-Bromotetrahydropyrans
| Autor: | A. Venkat Narsaiah, D. O. Biradar, Y. D. Mane, Y. P. Sarnikar, S. G. Kulkarni, B. V. Subba Reddy |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | SynOpen. :263-269 |
| ISSN: | 2509-9396 |
| Popis: | An efficient approach for the one-pot synthesis of 4-bromotetrahydropyrans in a highly diastereoselective manner via the alkynylation followed by Prins cyclisation is described. The method employs aldehydes and allyl bromide as reactants, with a Zn/ZnBr2 catalytic system in CH2Cl2. A variety of 2,6-disubstituted 4-bromotetrahydropyran derivatives were obtained in good yields. |
| Databáze: | OpenAIRE |
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