Pemphigus vulgaris is the most common autoimmune bullous disease in Northwestern Romania
| Autor: | Adrian Baican, Cassian Sitaru, Corina Baican, Victorina Macovei, Detlef Zillikens, Dorina Ciuce, Gabriela Chiriac, Mircea T. Chiriac |
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| Rok vydání: | 2010 |
| Předmět: |
Autoimmune disease
medicine.medical_specialty Pemphigoid education.field_of_study integumentary system business.industry Incidence (epidemiology) Pemphigus vulgaris Population Dermatology medicine.disease 3. Good health 030207 dermatology & venereal diseases 03 medical and health sciences Pemphigus 0302 clinical medicine 030220 oncology & carcinogenesis Epidemiology medicine Bullous pemphigoid skin and connective tissue diseases business education |
| Zdroj: | International Journal of Dermatology. 49:768-774 |
| ISSN: | 0011-9059 |
| Popis: | Background Autoimmune bullous diseases are organ-specific diseases characterized by autoreactive T and B cells specific for structural proteins of the skin. The incidence and prevalence of autoimmune blistering diseases vary in different countries and their epidemiology has not yet been addressed in Romania. Methods In this study between 2001 and 2007, we prospectively investigated a total of 116 patients with autoimmune blistering diseases from the Northwestern region of Romania. The diagnosis was based on the clinical, histo- and immunohistological as well as serological findings. Results Pemphigus was the most common disease representing 58.6% of the case (68 cases); 40 cases (34.5%) were diagnosed with bullous pemphigoid (BP) and eight cases (6.9%) with other autoimmune sub-epidermal diseases. The incidence and prevalence of pemphigus diseases were four patients/1 000 000 inhabitants/year and 0.00248%, respectively. BP occurred in 2.5/1 000 000 inhabitants/year and its prevalence was 0.00146%. While the average onset age for pemphigus vulgaris was 53 years, BP patients were first diagnosed at a mean age of 73.6 years. Conclusion The genetic background of the local population may explain why pemphigus occurs more commonly than BP in Northwestern Romania compared with the population of Western Europe. In addition, the shorter life expectancy in Romania (71.3 years) compared with Western Europe (>80 years) may contribute to this phenomenon. |
| Databáze: | OpenAIRE |
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