Reply to Lucock et al.: Significance of interpretation and misinterpretation of a small mechanistic study
| Autor: | Jia Zhong, Diane R. Gold, Andrea A. Baccarelli, Bruce Urch, Mary Speck, Petros Koutrakis, Frances Silverman |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Proceedings of the National Academy of Sciences. 114 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | The aim of our small mechanistic study (1) was to test the biologic plausibility that ambient particle pollution might have epigenetic effects on DNA methylation that could be modulated by methyl donor supplements. We acknowledge in this letter and in our paper that generalizability of our results is limited not only by study size, but also by the characteristics of healthy study participants. In contributing to the body of literature used for scientific assessment and consequent policy decision making, carefully controlled mechanistic studies like ours complement the large epidemiologic studies that, as Lucock et al. (2) suggest, show that reduction in ambient particle levels have led to improvement in health and reduction in morbidity and mortality (3⇓⇓–6). Studies like ours cannot diminish—nor be … [↵][1]1To whom correspondence should be addressed. Email: jiazhong{at}mail.harvard.edu. [1]: #xref-corresp-1-1 |
| Databáze: | OpenAIRE |
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